Describing Sizes and Dimensions in Spanish

Here are three common ways to express measurements in Spanish. Deciding which ones to use is largely a matter of personal preference since they are interchangeable in most cases.   1. Medir   This verb, which is conjugated irregularly, generally means to measure. Examples: Mido cinco pies y cinco pulgadas de alto. (I measure 5 feet, 5 inches tall.) Los cientà ­ficos hallaron un fà ³sil que mide dos metros de largo. (The scientists found a fossil that measures two meters long.) 2. Tiene This verb literally means to have. It can be used to directly indicate dimensions. It also is conjugated irregularly. Examples: El centro comercial tiene tres kilà ³metros de largo. (The commercial center is three kilometers long.) Si antes tenà ­a cinco metros de profundidad, ahora tiene dos. (If it was five meters deep before, its now two meters.) 3. Ser de This is the rough equivalent of saying in English that something is a certain size. Note the use of the preposition de, which is not translated to English. This method of describing dimensions is less common than the other two. Examples: El à ¡rea es de 160 metros cuadrados. (The area is 160 square meters.) Las dimensiones del nuevo almacà ©n son de 25 por 70 metros, y la altura es de ocho metros. (The horizontal dimensions of the new warehouse are 25 by 70 meters, and its height is 8 meters.)

Oedipus a Tragic Hero - 1516 Words

Oedipus A Tragic Hero English 102 Literature and Composition Summer B 2011 Terry Garofolo 22816762 APA Sophocles presented the world with Oedipus around 2500 years ago. Never-the-less, the story remains among the most riveting of all time. Unfortunately, today when we hear the mention of the name Oedipus we place negative connotations around it. Oedipus, after all, had an unnatural sexual relationship with his own mother! In actuality, however, this relationship emerged entirely innocently. Oedipus was not some misguided sexual pervert of an earlier time. He was, in fact, a man that was driven by a very high internal moral standard. It was that internal moral standard that ultimately entwined him in a sequence of events†¦show more content†¦The first part of the prophecy had thus been fulfilled despite Oedipus determination that it would not. It might be argued that Oedipus killing of his biological father was a result of inferior morals. In this time period, however, such a killing was viewed as reasonable, what any reasonable human being would have done under similar circumstances, and should not be used to disqualify Oedipus under Sophloles definition of tragic hero (Ades 358). This was not a murder for gain and neither was it a murder resulting from hatred. It was simply a socially acceptable means of settling a dispute. As was the case with the fulfillment of the first part of the prophecy, the fulfillment of the second part of the prophecy didnt occur either because of inferior morals on Oedipus part. Oedipus was welcomed into his birth country as a hero because he had killed the much feared Sphinx, the same Sphinx that the people of the country believed had murdered their king, Oedipus birth father. The Sphinx had been a killer himself. His favorite tactic was to prevent travelers from the kingdom unless they could answer the riddle of what moved on four legs in the morning, walked on two legs at noon and on three legs at night. Oedipus gave the correct answer of â€Å"man†. Man, after all crawled when he was an infant, walked upright through mostShow MoreRelatedOedipus As A Tragic Hero1506 Words   |  7 PagesA true hero does not merely wear a cape, but this individual possesses admirable characteristics. A hero inspires the people around him and he is honorable. Heroes influential individuals from fairytale stories and myths of a real-life hero. Yet, none of these influential people are perfect. The tragic hero is clearly defined by Aristotle as being a person of admirable character, yet completely human with noticeable flaws. Moreover, this individual is not exempt from suffering. In Sophocles’ tragicRead MoreIs Oedipus A Tragic Hero?1167 Words   |  5 Pages2014 Is Oedipus a tragic hero? Aristotle, Ancient Greek philosopher whom did a lot of philosophizing, he believed in a logical reality. Aristotle’s objective was to come up with a universal process of reasoning that would allow man to learn every imaginable thing about reality. The initial process involved describing objects based on their characteristics, states of being and actions. Aristotle once said A man doesn t become a hero until he can see the root of his own downfall†. Oedipus was a mythicalRead MoreOedipus As A Tragic Hero1724 Words   |  7 Pagesstory of Oedipus, Oedipus is considered a â€Å"Tragic Hero† because of the tragic fate and effect that he had upon his life. My definition of a tragedy is a great loss that has a unhappy ending to which concluded me to state that Oedipus falls under that category. Throughout the book, Oedipus is leading himself to his own destruction when trying to find the killer of the late King Laios. So when a journal article I found published by The John Hopkins University Press stated that a â€Å"tragic hero is a manRead MoreOedipus-a Tragic Hero706 Words   |  3 PagesRunning head: Oedipus-A Tragic Hero Research Paper ENGL 102: Literature and Composition) Fall 2015 Melinda Meeds L26683811 APA Outline Thesis: In Sophocles’ â€Å"Oedipus†, Oedipus is exemplified as a tragic hero according to Aristotle’s definition because his story appeals to the reader’s humanity in the way he maintains his strengths after inadvertently causing his own downfall. I. Oedipus A. The noble birth. B. Describe Oedipus’ character. II. Tragedy A. DescribeRead MoreOedipus the Tragic Hero1390 Words   |  6 PagesOedipus; The Tragic Hero In the Fourth Century BC, a famous philosopher named Aristotle wrote about the qualities that a tragic hero must possess. Ever since that time, there have been many examples of tragic heroes in literature. None of those characters, however, display the tragic hero traits quite as well as Oedipus, the main character from the play Oedipus Rex by Sophocles. Oedipus is, without a doubt, the absolute quintessence of a tragic hero. His example shines as clear as a sunny summerRead MoreOedipus, A Tragic Hero1648 Words   |  7 Pages Oedipus, a Tragic Hero Bob Livingston Liberty University â€Æ' Sophocles presented the world with Oedipus around 2500 years ago. Never-the-less, the story remains among the most riveting of all time. He was, in fact, a man that was driven by a very high internal moral standard. It was that internal moral standard that ultimately entwined him in a sequence of events and circumstances that placed him in the spousal relationship with his mother. Oedipus, in fact, can truly be regarded as a tragic heroRead MoreOedipus As A Tragic Hero1094 Words   |  5 PagesIn the play Oedipus the King, Oedipus struggles to accept the truth and lets his temper over power him. He can be displayed as a tragic hero. His refusal to accept the truth led to Oedipus’ down fall. A tragic hero, as defined by Aristotle, â€Å"is a literary character who makes a judgment error that inevitably leads to his/her own destruction.† Sophocles’ Oedipus exemplifies Aristotle’s definition of a tragic hero. In the play, Oedipus unknowingly has cursed the entire town of Thebes. He was cursedRead MoreOedipus, a Tragic Hero?2158 Words   |  9 PagesOedipus, a Tragic Hero? Elizabeth Howell English 102- B33 Professor Katie Robinson Liberty University October 12, 2012 Oedipus, a Tragic Hero? Thesis: Using Aristotle’s five different descriptions of a tragic hero, we will show that Oedipus in Oedipus the King is in fact a tragic hero and how his decisions led to his downfall. Outline: I. Introduction and Thesis Statement II. Is the character of noble birth? A. King of Thebes B. Real father was king III. Though the tragic heroRead MoreOedipus, A Tragic Hero1832 Words   |  8 Pagesmany others will likely fade away. Oedipus Rex is a tragic tale set in Ancient Greece. Greek thinker, Aristotle, said there were certain elements that would make a person qualified as a â€Å"tragic hero.† (Adade-Ywboah, Ahenkora Amankwah, 2012). We think of heroes being larger than life, possessing impeccable honor, integrity, strong leadership and having the higher moral ground. However, tragic heroes are different; they are imperfect and will inevitably face a tragic downfall. Per Aristotle, there areRead MoreOedipus As A Tragic Hero1445 Words   |  6 PagesAlthough not all who wander or deviate from the path are lost, some clearly are. When Oedipus, the eponymous character of Sophocles’ tragedy Oedipus Rex, first learns that he is destined to kill his father and marry his mother, he abandons his home intent on never returning in order to avoid meeting his fate. Unbeknownst to the tragic hero, before the curtain’s rise, the prophecy has already been fulfilled. Consequently, due to the underlying corruption in Thebes, the people are perishing of a plague

Areas of Learning Free Essays

|Area |Extending learning and development | |Quiet/reading area |The quiet area allows children to develop their understanding of the written word; they learn that words convey meaning and that| | |this is mirrored by the pictures that are in the books. | |They develop interaction with others through the use of books and listening | | |They learn to share and co-operate | | |They learn concentration and self control | | |They learn about the world around them, concepts, ideas and morals | | |They learn to take care of possessions | |Small world |The children learn to role play and to share and take turns with others | | |They learn social interaction and effective communication | | |The learn tolerance and understand of other people’s ideas and beliefs | | |The develop their fine motor skills | | |They learn about the world in which they all live | |Role play |The children learn to role play, to pretend and to accept other’s as part of that pretence | | |They learn to socialise, to share toys and ideas | | |They develop their imagination | | |The imitate talk and behaviour | | They learn to dress themselves | | |The develop their ability to take on a role and develop it | | |They share and take turns | | |They mark make | | |They mimic and copy | |Mark making |In mark making they learn to use different mediums to create marks | | |They develop their fine motor skills | | |They extend their language | | |They make decisions, take turns and share | | |They develop an understanding of the written word and learn that words convey meaning | | |The improve their manual dexterity and hand eye co-ordination | | |They develop their understanding of topics and show pride in their achievements They learn to write, draw and recognise colour | | |They develop control and concentration | |Maths/ICT |In this area they learn more/less | | |They will develop problem solving and logic | | |The children will learn to communicate and develop the use of mat hematical language | | |They will learn hand eye-co-ordination, fine and gross motor skills | | |They will develop their understanding of number, counting and it’s symbolic representation | | |They will compare, contrast, match and sort (using various criterion) | |They will develop and awareness of computer and mouse control | | |They will learn to share and take turns | |Craft |The children will use a variety of different mediums to create | | |They will develop fine motor skills and hand eye co-ordination | | |They will learn about colour, pattern and texture | | |The will use their imagination and draw upon their understanding of the world in which they live. | |The children develop their creative awareness and independence | | |They will use imagination and problem solving | | |The will develop their social skills, communication and co-operative skills | | |The will begin to develop self-expression , confidence and creative flair | |Outside |The children will under stand the environment, learning about weather and the world in which they live | | |They will develop their spatial awareness /gross motor skills | | |The will explore their manipulative skills/sense of balance/agility skills/risk taking | | |The will develop their spatial awareness/fine manipulative/gross motor skills | | |They will develop their hand-eye and foot-eye co-ordination/ locomotive skills | | |They will develop social skills, turn taking, sharing and creativity | | |They will develop their language and communication skills | |They will develop their confidence and awareness of their own capabilities as well as pushing themselves a little more to learn | | |new skills | Whilst the children are learning through their play and through all the skills and areas above we will monitor and support them in order to help them develop in the right way. We will write a custom essay sample on Areas of Learning or any similar topic only for you Order Now We will encourage good behaviour and discourage negative behaviour. We will give the children confidence to develop their skill set, confidence and capabilities. We keep a continual record of their achievements so that we can monitor their progress and highlight and areas for special consideration. In this way we will engender high levels of expectation and achievement. How to cite Areas of Learning, Papers

Opportunities and Challenges Related to Electronic Health

Question: Discuss about the Opportunities and Challenges Related to Electronic Health. Answer: Introduction: My health record is the new application of commonwealth Government of Australia to secure online health information of the individual. My health record system is accessible to all Australian to drawn their existing records of their information which is available in the local clinical system. The health care system wants to improve the quality of facilities provided to the patients. Individuals are able to upgrade their health record which is available online. The doctors and patient can share the health information to provide best care. The good health of the citizens is the building block of the glory and prosperity of the country. In this paper, we are going to focus the problems in the current health system and capabilities and benefits of the My health record system. From the research and survey, we analysed that the population of America are facing the problem of ageing, increased rate of chronic diseases, cost of health care, poor quality of facilities, incomplete collection of health records reports, lack of registered user, lack of clinical and system use, doctors unable to diagnose the cause of the disease, and many others. My health record system is the solution to the problems which are faced by the population of Australia. Customers and patients can do online registration into the portal to get best quality services, facilities, and care of the service providers (Foley, 2015). The health of the Australian population can be improved and managed by the implementation of my health record system. The newer system for improving health of the Australians should be comprised of the following features: A mechanism of communication to maintain flow of information between health care system and the population of Australia. The information related to the common services provided to the Australian should be notified in the patient record such as information about regular check-up, blood pressure. Diabetes or any new chronic disease. The population of Australia is participating in doing registration in the system for getting better facility of health care. The shard repository system provides the centralization to the information of patients across Australia (Denney, 2015). The doctors and patients can share information for the diagnosis of the disease. The doctor can go through the historical data of the patient for knowing the cause of illness. This techniques helps in providing better diagnose facility and the patient can get medicine at the starting stage of the disease which make him fit in the short period of time. The patient identity proof should be deposited during the registration for the interpretation and interrogation of the information (Partel, 2015). It also helps in overcoming the problem of errors occurred in saving the data. It emphasis to store right data in right account. Information access layer is the interface between the user and the stored data. Benefits: The technical security is provided to the records stored of the individual in my health record system. It prevents leakage of information related with the identity of the patient (Bowles, 2012). The population of Australia is participating in doing registration in the system for getting better facility of health care. The training module of the system built a training platform to provide best practices training to the stakeholder related to exercise or other plans for their good health. The consumer get rebate on the medical facilities. The shard repository system provides the centralization to the information of patients across Australia. The doctors and patients can share information for the diagnosis of the disease. The doctor can go through the historical data of the patient for knowing the cause of illness. The patient can get treatment at lowest cost. The implementation of this system result into the decreasing rate of chronic disease. The software works in coordination with na tional health record system to get best doctors for diagnosing the cause of disease (Herrick, 2010). Easy interface of the system attracts the consumer to become a member of the system (Morton, 2008). Public education campaign notification can be send to the consumer account. The user can update their health records and doctors prescription in their account. Performance monitoring system helps in analysing the growth of health of Australians. Conclusion: The implementation of my health record system works in the direction of improving the health of the Australians. The quality of the health care facilities provided to the consumer can be improved to high extent. The people can get treatment at lowest price. The health of the Australian population can be improved and managed by the implementation of my health record system. The good health of the Australians will result into the prosperity of the country. References: Bowles, M. (2012). Accelerating the delivery of benefits from australias investment in the national e-health system (1st ed.). Retrieved from https://myhealthrecord.gov.au/internet/mhr/publishing.nsf/Content/consultation-submissions/$FILE/069%20-%20Deloitte%20Touche%20Tohmatsu.PDF Denney, J. (2015). Opportunities and challenges related to the use of electronic health records data for research (1st ed.). Retrieved from https://www.nih.gov/sites/default/files/research-training/initiatives/pmi/opportunities-challenges-electronic-health-records.pdf Foley, E. (2015). Electronic health records and health care identifiers (1st ed.). Retrieved from https://myhealthrecord.gov.au/internet/mhr/publishing.nsf/Content/consultation-submissions/$FILE/063%20-%20Research%20Australia.PDF Herrick, D. (2010). Health information technology: Benefits and problems (1st ed.). Retrieved from https://www.ncpa.org/pdfs/st327.pdf Morton, E. (2008). Use and acceptance of an electronic health record: Factors affecting physician attitudes (1st ed.). Retrieved from https://www.google.co.in/url?sa=trct=jq=Research+paepr+pdf+on+My+health+recordsource=webcd=7cad=rjauact=8ved=0ahUKEwjpna_4zeXSAhVFmJQKHb0rAIQQFghIMAYurl=https://idea.library.drexel.edu/islandora/object/idea%253A2905/datastream/OBJ/download/Use_and_acceptance_of_an_electronic_health_record__factors_affecting_physician_attitudes.pdfusg=AFQjCNEhZQtl6pBPFoZVheM6N2B2a_Jadwbvm=bv.150120842,d.dGo Partel, K. (2015). Towards better implementation: Australias my health record (1st ed.). Retrieved from https://apo.org.au/files/Resource/deeble_institute_issues_brief_no_13_partel_toward_better_implementation_my_health_record.pdf

The Villain Comparison Creon in Antigone and Medea in Medea

Who is a greater villain and why: Creon in Antigone or Medea in Medea? Is there a way to see one or both of them as not being a villain? The two classics provide a comprehensive analysis of diverse roles of women. In Medea, for instance, the Medea employs figurative speech to explore the social injustices that repeatedly touches on the social aspects of women. From such a position the audience is allowed to examine the position of a woman in the society. The position in this case touches on woman subordination to man and this are inextricable from the innate features surrounding the social order during this period in Greece. Advertising We will write a custom essay sample on The Villain Comparison: Creon in Antigone and Medea in Medea specifically for you for only $16.05 $11/page Learn More Hence, in Medea the audience is permitted to explore the suffering of a woman who has been rejected, twisted and abused because of her gender. In essence, this demons trates how woman was treated in the Greek society. What this signifies is that the woman is painted as a social misfit and this resulted in Medea going against the social prescription of a married woman. However, when we examine the approaches employed by Antigone it becomes obvious that she Antigone was a reflection of a woman at home. However, the conflict that ensued between her and Creon provides a new dimension to the entire setting of the plot. Consider the fact that Creon is depicted as a tyrant in the play. This is testified in the manner he handles the issue regarding the burial of Polyneices, Antigones slain brother (Fagles 142). From a tragic perspective his rigid stance on the social injustices makes him to be a villain. When Media is exiled one is left pondering what would it be for a woman to live as a villain. This concept paints Media as a heroine while in Antigone Creon is depicted as a ruthless villain. All in all, despite their differences the two characters can be explored in a similar light. Consider the fact that Creon employed ruthless tactics to guard his position in the society. Equally, Medea utilized her personality to speak against the social injustices that touched on woman affairs in the society. The way Medea is portrayed as submissive equally matches Creon persistence in protecting his position as the leader. Also, Medea stands out as the symbolism of early aspects of feminism. And this compares with Creon approach to the social life examined in Antigone. Looking at the two characters it is thus possible to argue there exists another angle of examining them both as being heroes rather than being villains in their respective social standings. For instance, Creon handled Antigone and rejected the idea of her burying her brother for as a leader he considered doing so would encourage revolt against the ruling class, while on the other hand Medea stood strong in conviction that being submissive gave her strength to live as a woman. Despite the contrast and the approach employed in both Greek tragedies the two characters do share diverse but unique similarities (Fagles 154).Advertising Looking for essay on literature languages? Let's see if we can help you! Get your first paper with 15% OFF Learn More In both cases justice is the core element that has been examined. Looking at the character depicted by Creon we find the crude power generated by greed while Medea reveals the strengths of being a woman despite the social challenges. In such a situation it becomes essential to assert that Creon symbolized evil and that is why he is depicted as a villain. However, he had a soft spot that made him to be a hero. Work Cited Fagles, Robert. The Three Theban Plays. New York: Penguin, 1999. This essay on The Villain Comparison: Creon in Antigone and Medea in Medea was written and submitted by user Clayt0n to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

13 years, 9 guys, 1 goal the story of the 2002-2003 Sam Rayburn Rebel High School Varsity Basketball Team

13 years, 9 guys, 1 goal the story of the 2002-2003 Sam Rayburn Rebel High School Varsity Basketball Team 13 years, 9 guys, 1 goal13 years, Nine Guys, One Goal! Some of you, whether it's baseball, softball, or bull riding, have a passion for a particular sport, in my case its basketball. In my last year of high school, I was a part of a varsity basketball team that had a tradition of losing. It had been thirteen years since the Sam Rayburn Rebels had made it to the postseason. Talented team, after talented team failed to make the playoffs for thirteen years. But last year nine guys decided to change everything and hang a district co-championship banner atop of the gym. I would like to inform you about the hard work that was involved in our efforts to bring the word "playoffs" back into the Sam Rayburn vocabulary. Then I will mention the relationship between the members of the team, and lastly, our achievements throughout the season.Sam Rayburn House, Bonham, Texas Historical MarkerIn order to achieve our goals, we knew that we were gong to have to put in many hours, and many longs days o f practice in the gym. We did just that. Most people don't even get up at 6:00 in the morning, but our team was actually inside of the school gym doing shooting drills by 5:45. And after school, we would stay till 6:00 at night and occasionally till 7:00. We would do this Mon-Fri every day, not because our coach made us but because we wanted so desperately to make the playoffs and end the so-called curse. The mornings before games we would get up extra early so we would have just enough time to watch the film of our previous game.If you plan on reaching the goals you have set out for yourself, not only do you have to have good work ethic but you...

Zero Tolerance and Public Shaming Essay Example | Topics and Well Written Essays - 750 words

Zero Tolerance and Public Shaming - Essay Example However, public shaming, especially for crimes by the powerful who are public office bearers such as Members of Parliament, can be very effective in reducing crime or any other related bad practice since they ought to be accountable to the members of the public which they will be representing. Statistics show that about 14 percent of the Australian economy is a shadow economy that involves multiple criminal offences meant to evade the payment of company tax, payroll tax as well as personal income tax and it stands to reason that zero tolerance, in this case, will condemn about 14 percent of the Australian population to the prison which would be counterproductive to the economy of the nation as a whole. At least less tough measures would be advocated in such crimes of this magnitude which aim to generate preventive measures to such kind of problems. Zero tolerance will create a population of rule following people who always fear prosecution instead of allowing them to think systematically as team players with regards to problem prevention. In cases of organized crime such as genocide, zero tolerance would only punish minnows while the big sharks can get off the hook with impunity. It can be noted that zero tolerance to crime either by the powerless or the powerful is not a very effective remedy that can totally put an end to criminal activities. To a certain extent, public naming and shaming are stigmatizing especially if it involves juveniles who are underage. By shaming these in the public, they would end up feeling alienated from their respective communities and would even behave as criminals as a result of the labeling perspective attached to them. With regards to public office holders, public but respectful naming and shaming can be effective in attempting to make these officials accountable to the people they serve. Powerful office bearers often employ the services of public relations experts to counter any negative story about their official conduct.

Budget Control Methodology Essay Example | Topics and Well Written Essays - 1750 words

Budget Control Methodology - Essay Example Control Centers To build a budgetary control hub together with your business clusters. Usually, responsibility centers are classified into four; investment, revenue, profits and expense. Conventionally, these are characterized by income and cash flow account. Together, these statements have ordinary interconnections, which can be scrutinized with time to achieve equilibrium. The working capital formula derived from the value of current assets minus current liabilities qualifies as a general assessment tool for investors while judging company's basic operational competence. Capital values affixed to any inventory, also known as current assets or money owed to the firm by clients, which is the current liabilities, may not be utilized to settle up a firm’s financial liability. When the flow of working capital is delayed between different cycles, then inefficiency is said to have occurred (Brownell 1985). Forecasting Forecasting is the most decisive element in a budgetary techniqu e. This entails the capacity to chart out a well planned strategy for future prospects. Simply, forecasting is deliberating on potential aspect that may arise in coming days. Every manager is obliged to organize specific drafts, showing objectives and capital requirements. These needs should be assessed against the larger outlook to guarantee compatibility with business standards. A lot of emphasis should be directed towards setting up a responsive budget, which presents proportions of general accounts for relevant sectors. Budgeting should be considered as a device in addition to a control measure (Little et al. 2002). 2. Costing methodologies: While examining costing methods, several methods may be applied to establish expenditure proportionate to administrative obligations. These applications may be classified as follows: Absorption costing: this denotes the guarantee of expenses after they are incurred according to the structure - both fixed and unpredictable costs are apportion ed to cost units while the sum total of overheads is taken up by real activity levels. Absorption costing is defined as total costing owing to the fact that total costs are final amounts assigned to costs. This is also submitted as a standard or time based costing. Still, due to the reality that costs are certified after they have been acquired, and large time-gaps subsist from the point of expenditure to the time of cost citation, it is evident that it does not mitigate cost control. Marginal costing: this system illustrates the theory whereby variable expenses are levied to expenditure units, whereas fixed costs associated with the related duration is settled up wholly versus the input in the given timeframe. The contribution noted marks the variation between sales and the subsidiary cost of sale. Marginal costing can be described as a straight or variable costing.   The technique is a vital tool to the management while deliberating on crucial guidelines, which include pricing, product preference and final choice. Standard costing: this strategy employs standard for costs and returns with a view to management through a variance investigation. Values are set up according to each cost factor on a systematic basis for nonstop future prospects, while actual expenses are weighed up against the same standards. Discrepancies accrued from standards are investigated; logical causes are formed and remedial measures put in place to deter a repeat of wasteful business practices. Differential costing: the technique is mainly concerned with

Human rights and armed conflict Essay Example | Topics and Well Written Essays - 750 words

Human rights and armed conflict - Essay Example The paper describes the patterns, developments, controversies, problems and major sub-issues regarding each issue. As part of this paper, the relationships between the two issues and possible solutions that are effective in the next twenty-five years are discussed. Armed conflicts refer to the armed conflicts between two or more organized parties in disputes about power over government and territory (Moir, 2002 p210). There are 118 armed conflicts that ensued between 1990 and 1999, of which ten were strictly inter-state conflict. Five were wars of independence, and one hundred wars were primarily internal conflicts. Violent conflicts in Europe, including Turkey, Caucasus and Russia, accounts for two-thirds of the increased incidents of wars in the early 1990s (Moir, 2002 p210). Europe in the early 1990s became one of the most violent regions in the world. The annual reduction in the number of conflicts after 1992 is as a result of changes in Europe. There are a number of factors that led to the rise of international and regional armed conflicts. Poor economic status of different nations is the leading cause of intra-state armed conflicts in the modern world. The greatest challenge facing the current governments is resource allocation. The reso urces are limited in supply, and their demand is high. Most governments normally allocate more resources to urban centers and regions that are highly productive than dry, remote area. This makes some local governments feel neglected by the central governments, and this may cause conflict between different local governments (Moir, 2002 p211). Repressive political systems in transition periods are also the other significant cause of intra-state armed conflicts. Reformists and opposition parties are often witnessed organizing riots to protest against some political policies introduced by the sitting authority. This sometimes grows worst to appoint

Expression of TDP43 in Development of ALS Model Zebrafish

Expression of TDP43 in Development of ALS Model Zebrafish Change in expression of TDP43 in various organs during development of ALS model zebrafish. Anuj Dhoj Raut Introduction Amyotrophic lateral sclerosis (ALS) is the devastating motor neuron disease that is characterized by progressive degeneration of both upper and lower motor neuron that control voluntary movement of body. The degeneration of the neurons seen in ALS result in muscle weakness, spasticity and atrophy of both cranial and spinal nerves muscle groups. Since there is often respiratory muscle involvement, aspiration pneumonia is the most common cause of death for the patients with ALS. At present, ALS is invariably fatal disease with no absolute cure and patients usually die within 3-5 years after the clinical onset of symptoms. The mean age of onset of ALS is between 55 and 65 years with slightly more prevalence in male (Male: Female ratio ~ 1.5:1) (1). Even though, incidence rate of ALS are different in different countries of the world, globally average annual incident rate is between 1.5 and 2.5 per 100,000 populations. There has been an increase in death rate of ALS and current internatio nal death rates for ALS have be close to 1 per 100,000 population per year(1). Currently, riluzole, an inhibitor of glutamate release, is the only disease modifying treatment available for the disease and can extends life only for couple of months (2,3). The etiology of ALS is currently unknown. However, approximately 10% of ALS patients have family history for ALS (Familial ALS;FALS) and remaining 90% of case occur sporadically (Sporadic ALS; SALS)(4). Although definitive evidence for environmental factor that cause ALS has remain mostly unknown, the evidence of genetic alternation that cause ALS has been increasing. Till date, only known cause of ALS is mutation in the gene. Mutations in more than 13 different types of genes have already been identified that can cause FALS. FALS is often a Mendelian inheritance with high penetrance, although most cases are autosomal dominant pattern of inheritance, autosomal recessive pedigrees have also been reported (5,6). Even though, FALS are cause due to genetic alternation, FALS are indistinguishable from SALS form histopathological perspective and both the types’ presents with similar sign and symptoms, thus suggesting common intra-cellular processes that lead to the disease symptoms. Among those 13 different types of gene mutation that causes FALS, mutation in Transactive response DNA binding Protein 43kDa (TDP-43) gene is seen in approximately 4% of FALS and 2% of SALS (7). Transactive response DNA binding protein 43kDa (TDP-43) is a DNA/RNA-binding protein encode by the TARDBP gene on chromosome 1. TDP-43 is an ubiquitously expressed nuclear protein capable of shutting between the nucleus and cytoplasm (8). TDP43 is present in almost all the tissue of a body and have different roles in different tissues (9). Although the precise cellular function of TDP-43 is unknown, TDP-43 has been implicated in regulating of gene transcription (9),alternative exon splicing (10) and mRNA stability (11). Under normal physiological conditions, TDP-43 resides predominantly in the nucleus where it involved in gene expression. But, in abnormal pathological conditions such as ALS, TDP-43 is mislocalized in the cytoplasm as inclusions body (12,13) . Analysis of TDP-43 in the brain and spinal cord of ALS patients reveled that TDP-43 is pathologically modified and redistribution to the cytoplasm, which is accompanied by loss of normal nuclear function and a toxic gain-of-function in the cytoplasm (14,15). The mislocalization of TDP-43 into cytoplasm is believed to be cause of neuron loss in ALS patients. Moreover, TDP-43 positive inclusions are also found either independent or partially colocalize with the other characteristic inclusion, such as tau, ÃŽ ±-synuclei, ÃŽ ²-amyloid and polyglutamines, which are found in other neurodegenerative disease such as Alzheimer’s disease, Pick disease and Parkinson’s disease. Interestingly, TDP-43 positive cytoplasmic inclusion are found in almost all ALS patient along with other neurodegenerative disease (16). Although evidence suggest that there is a definitive association between ALS and TDP-43, above observations make it confusing to whether TDP-43 pathology is causative or a secondary response in this disease. Studies done to unravel if TDP-43 is pathology or secondary response to ALS have come with conflicting result. Moreover, the present of TDP-43 in inclusion body of another neurodegenerative has been a mystery. The precise role of TDP-43 in ALS and other neurodegenerative disease is not well known and needs further evaluation. Study, in the mouse has shown that TDP-43 protein is essential for normal prenatal development. Homozygous loss of TDP-43 in mouse cause early embryo death. But, in heterozygous loss TDP-43 mouse, the TDP-43 protein levels were nearly normal suggesting an auto-regulatory mechanism controlling this protein levels(17,18). Moreover, research on mRNA expression levels of TDP-43 protein in various tissues has shown that TDP-43 plays different roles in different tissue(9). Furthermore, about 40 different mutant in TDP-43 have already been identified so far that is associated with ALS (10). But all this various types of mutations in TDP43 have only affected motor nerve of spinal cord and brain. At the same time, mutation and/or overexpression of TDP-43 has not cause any pathology alternation in other cells and tissue of the body or has been found to be associated with diseases of other organ system. A protein that is so vital for a development of organisms that it’s absent cause deat h, but when there is mutation in its gene has only abnormalities in nervous system and that abnormalities are evidence after mid-life is yet to be understood. Moreover, within the nervous system mutation in TDP-43 seems to affect only motor neuron and at the same time spares other neuron such as sensory, autonomic nervous system. And this preference to the motor neuron by mutant TDP-43 is even seen till the late stage of the disease. Physiological roles of TDP-43 and early cellular pathogenic effects caused by disease associated mutations in differentiated neurons is yet to be fully understand. Causative link between TDP-43 positive inclusion and ALS can be well established, if nuclear to cytoplasmic expression of mutant TDP-43 could be study in vivo and in real time. And at the same time, will also be able to understand if TDP-43 pathology is causative or a secondary response to ALS and other neurodegenerative disease. Transgenic rodent models of ALS have been extremely valuable in providing some insight into biological mechanisms underlying ALS. But, due to difficulty in conducting in vivo real time study with rodent, change in intra cellular expression of TDP-43 has not being well understand. The zebrafish has recently emerged as powerful genetic model system for studying ALS. External development and transparency make it great tool to study the development stages of almost all the organ. External development of its eggs allows easy observation and manipulation of early development process. And, transparency makes is a powerful tool to observe the change at cellular level by using fluorescent reporters. With the help of fluorescent reporter, specific cell type and protein expression within those cells can be easily identify and study in vivo and in real time in zebrafish. In addition, zebrafish is a vertebrate and their nervous system is highly conserved with higher vertebrates including humans a nd many pertinent feature of the nervous system start to develop within 1 day of development. Moreover, genetic manipulations are comparatively easy in zebrafish. Therefore, zebrafish is a great model system to study the association of TDP-43 and ALS. In this study, I am trying to understand the change in expression of mutant and overexpressed TDP-43 protein in different tissue of zebrafish. At the same time also will be evaluating the change in expressions of TDP-43 as the zebrafish grow from embryo to adult. I will then compare the change in level of TDP-43 from asymptomatic stage of ALS zebrafish to that of symptomatic stage of ALS zebrafish. In order to conduct this experiment, transgenic zebrafish with human mutant TDP-43 will be created by genetic engineering. Human mutant TDP-43 will be fused with green florescent protein (GFP) before creating transgenic zebrafish. By combining human mutant TDP-43 with GFP will allow easy visualization of TDP-43 protein in zebrafish. Then, image of the fluorescent labeled TDP-43 at different stage of development of zebrafish period will be capture with fluorescent microscope. References 1.Logroscino, G., Traynor, B., Hardiman, O., Couratier, P., Mitchell, J., Swingler, R., and Beghi, E. (2008) Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues. Journal of Neurology, Neurosurgery Psychiatry 79, 6-11 2.Bensimon, G., Lacomblez, L., and Meininger, V. (1994) A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. The New England journal of medicine 330, 585-591 3.Miller, R., Mitchell, J., Lyon, M., and Moore, D. (2007) Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Cochrane Database Syst Rev 1 4.Pasinelli, P., and Brown, R. H. (2006) Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nature Reviews Neuroscience 7, 710-723 5.Mulder, D. W., Kurland, L. T., Offord, K. P., and Beard, C. M. (1986) Familial adult motor neuron disease: amyotrophic lateral sclerosis. Neurology 36, 511-517 6.Gros-Louis, F., Gaspar, C., and Rouleau, G. A. (2006) Genetics of familial and sporadic amyotrophic lateral sclerosis. Biochimica et biophysica acta 1762, 956-972 7.Corrado, L., Ratti, A., Gellera, C., Buratti, E., Castellotti, B., Carlomagno, Y., Ticozzi, N., Mazzini, L., Testa, L., and Taroni, F. (2009) High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis. Human mutation 30, 688-694 8.Winton, M. J., Igaz, L. M., Wong, M. M., Kwong, L. K., Trojanowski, J. Q., and Lee, V. M.-Y. (2008) Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. Journal of Biological Chemistry 283, 13302-13309 9.Ou, S., Wu, F., Harrich, D., Garcà ­a-Martà ­nez, L. F., and Gaynor, R. B. (1995) Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. Journal of virology 69, 3584-3596 10.Lagier-Tourenne, C., Polymenidou, M., and Cleveland, D. W. (2010) TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Human molecular genetics 19, R46-R64 11.Strong, M. J., Volkening, K., Hammond, R., Yang, W., Strong, W., Leystra-Lantz, C., and Shoesmith, C. (2007) TDP43 is a human low molecular weight neurofilament ( h NFL) mRNA-binding protein. Molecular and Cellular Neuroscience 35, 320-327 12.Arai, T., Hasegawa, M., Akiyama, H., Ikeda, K., Nonaka, T., Mori, H., Mann, D., Tsuchiya, K., Yoshida, M., and Hashizume, Y. (2006) TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochemical and biophysical research communications 351, 602-611 13.Mackenzie, I. R. (2007) The neuropathology of FTD associated with ALS. Alzheimer Disease Associated Disorders 21, S44-S49 14.Kabashi, E., Lin, L., Tradewell, M. L., Dion, P. A., Bercier, V., Bourgouin, P., Rochefort, D., Hadj, S. B., Durham, H. D., and Velde, C. V. (2010) Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo. Human molecular genetics 19, 671-683 15.Neumann, M. (2009) Molecular neuropathology of TDP-43 proteinopathies. International journal of molecular sciences 10, 232-246 16.Da Cruz, S., and Cleveland, D. W. (2011) Understanding the role of TDP-43 and FUS/TLS in ALS and beyond. Current opinion in neurobiology 21, 904-919 17.Kraemer, B. C., Schuck, T., Wheeler, J. M., Robinson, L. C., Trojanowski, J. Q., Lee, V. M., and Schellenberg, G. D. (2010) Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis. Acta neuropathologica 119, 409-419 18.Sephton, C. F., Good, S. K., Atkin, S., Dewey, C. M., Mayer, P., Herz, J., and Yu, G. (2010) TDP-43 is a developmentally regulated protein essential for early embryonic development. Journal of Biological Chemistry 285, 6826-6834

Girls and Selfie Culture: Empowering or Narcissistic? Essay -- self-est

Art, specifically the self-portrait, has evolved along with technology and social media. With the technological generation, the self portrait has become a selfie. But what sort of social implications come along with this new trend? Thesis Statement: Selfies give women and girls the power to represent themselves the way they wish to be seen, boost self-esteem, and could even shift the standard of beauty to something more realistic. How Selfies got Started In any art history class, there is one topic that is always covered: the self-portrait. All great artists from Leonardo Da Vinci to Jackson Pollock have immortalized themselves in the form of autobiographical portraiture. Female self portraits are specifically significant. Until the 20th century, women were rarely trained in the art of painting. Usually, the only female artists were the daughters of male artists. This was because it was necessary for apprentices of artists to live and work with the senior artist. Of course, it was socially unacceptable for a woman to live with a man to whom she was not married. Therefore, most portraits of women pre-20th century are not self portraits, but instead portraits painted by male painters. We can recognize these portraits by the fact that the subject’s gaze is never at the viewer, but rather to the side or downwards, due to the fact that women were not meant to look men in the eye. One female artist pre-20th century who created a famous self-portrait is Marie-Denise Villers. Her most famous painting, Young Woman Drawing, was once thought to be the work of Jacques-Louis David. According to the Metropolitan Museum of Art, â€Å"many paintings, especially portraits of young women, which were formerly attributed to Jacques Louis David or... ...pinto, Lauren. "Artist Selfies: Everybod'ys Doing It." Muddy Colors (blog), January 23, 2014. http://muddycolors.blogspot.com/2014/01/artist-selfies-everybodys-doing-it.html (accessed March 3, 2014). Ryan, Erin Gloria. "Selfies Aren't Empowering. The'yre a Cry for Help.." Jezebel (blog), November 21, 2013. http://jezebel.com/selfies-arent-empowering-theyre-a-cry-for-help-1468965365 (accessed March 1, 2014). Simmons, Rachel. "Selfies Are Good for Girls." Slate (blog), November 20, 2013. http://www.slate.com/articles/double_x/doublex/2013/11/selfies_on_instagram_and_facebook_are_tiny_bursts_of_girl_pride.html (accessed March 1, 2014). Winter, Jessica. "Selfie-loathing." Slate (blog), July 23, 2013. http://www.slate.com/articles/technology/technology/2013/07/instagram_and_self_esteem_why_the_photo_sharing_network_is_even_more_depressing.html (accessed March 1, 2014).